BeiGene Provides Updates of Tislelizumab in P-III (RATIONALE-309) Trial as 1L Treatment of Recurrent or Metastatic Nasopharyngeal Cancer Presented at ASCO 2022
Shots:
- The P-III (RATIONALE-309) trial evaluates tislelizumab (200mg) + CT vs CT + PBO in 263 patients with RM-NPC
- The results showed an improvement in PFS at a median follow-up of 15.5mos., m-PFS (9.6mos. vs 7.4mos.) while m-PFS2 (not reached vs 13.9mos.), positive OS trend was observed with m-OS (not reached vs 23mos.) & benefit across other survival EPs. The safety profile was manageable & consistent with the known risks profile
- The biomarker analyses for exploratory EPs including PD-L1 & GEP showed an improvement in PFS regardless of PD-L1 status, PFS benefit in patients exhibiting ‘hot’ tumor microenvironment profiles. The company continues to support the regulatory filings for NPC in the US & EU
Ref: Businesswire | Image: BeiGene
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